报告题目： 肿瘤表观遗传及生物标志物的基础与转化

报告人：新加坡基因组研究院  于强 教授

报告时间： 2019年3月22日下午4:00

报告地点：江阳路北校区19-810

主办单位：医学院（转化医学研究院）

报告人简介

      于强，新加坡基因组研究院癌症生物及药理学资深实验室主任，兼职新加坡国立大学医学院教授、新加坡DUKE-NUS 医学研究院教授。 教育部“长江学者”讲座教授 。专注肿瘤分子标记物及靶标，耐药及转移机理，开发分子诊断及液体活检技术。在肿瘤表观遗传学靶标及生物标志物方面做了许多前沿性的工作。作为通讯作者多次在Nature Medicine, Cancer Cell, Cancer Discovery, Molecular Cell, Genes & Dev, PNAS, JCI, JEM等杂志上发表文章。

代表性文章

1. Jian Yuan Goh, etc… Qiang Yu, Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence. Nature Medicine, 23, 1319–1330 (2017) 

   Yen-An Tang, Yu-feng Chen, Yi Bao, Sylvia Mahara, Siti Maryam J. M. Yatim, Gokce Oguz, Puay Leng Lee, Min Feng, Yu Cai, Ern Yu Tan, Sau Shung Fong, Zi-huan Yang, Ping Lan, Xiao-jian Wu, and Qiang Yu. Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer. PNAS June 26, 2018. 115 (26) E5990-E5999

2. Sylvia Mahara, .. Wee Joo Chng, and Qiang Yu. Hypoxia inducible factor 1-alpha activation underlies a functional switch of paradoxical role of EZH2/PRC2 in breast cancer.  PNAS 2016 Jun 28;113(26):E3735-44.

3. Wee at al…. Qiang Yu "IRAK1 is a therapeutic target that breast cancer metastasis and resistance to paclitaxel." Nat Communication. 2015 ; 6 : 8746 

4. Tan J, Li Z, Lee PL, Guan P, Aau M, Lee ST, Feng M, Lim CZ, Lee EY, Wee ZN, Lim YC, Karuturi RK, Qiang Yu. "PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy." Cancer Discovery, 2013 Oct;3(10):1156-71

5. Feng M, Bao Y, Li Z, Li J, Gong M, Lam S, Wang J, Marzese DM, Donovan N, Tan EY, Hoon DS, Qiang Yu. "RASAL2 activates RAC1 to promote triple-negative breast cancer progression." J Clin Invest, 2014 Dec;124(12):5291-304 

6. Shuet Theng Lee, Zhimei Li, Zhenlong Wu, Meiyee Aau, Peiyong Guan, R.K. Murthy Karuturi, Yih Cherng Liou and Qiang Yu ."Context-Specific Regulation of NF-kB Target Gene Expression by EZH2 in Breast Cancers". Molecular Cell ,43, 798–810, 2011. 

7. Jing Tan, .. Shing Chuan Hooi and Qiang Yu. B55β-associated PP2A complex controls PDK1-directed Myc signaling and modulates rapamycin sensitivity in colorectal cancer. Cancer Cell, 18:459-471, 2010 

8. Xiaojing Yang…and Qiang Yu. miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes & Development . 2009 23: 2388-2393. 

9. Xia Jiang, etc.. Qiang Yu. DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell. 13:529, 2008.

10. Jing Tan, Xiaojing Yang, Li Zhuang, Xia Jiang, Wei Chen, Puay Leng Lee, RK Murthy Karuturi, Patrick Boon Ooi Tan, Edison T. Liu and Qiang Yu. Pharmacologic disruption of Polycomb repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes & Development. 2007 21:1050.